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Current Projects
Current Projects
Naya Lab
Naya Lab
I study the coordination of metabolism and differentation through the Dlk1-Dio3 non-coding RNAs locus in skeletal muscle. My current projects utilizes cell culture, molecular analysis, and animal models to elucidate coordinate regulation of both metbaolism and diffenettion through gene regulatory networks in skeletal muscle development and regeneration.
CRISPR Deletion: Dlk1-Dio3 Locus
CRISPR Deletion: Dlk1-Dio3 Locus
I am currently working to characterize the phenotype induced by a CRISPR deletion in C2C12 muscle cells which will provide insights into the role of the Dlk1-Dio3 locus in skeletal muscle regeneration. (Imaged adapted from Dill, 2018)
LAMA2-related Congenital Muscular Dystrophy
LAMA2-related Congenital Muscular Dystrophy
In collaboration with Pfizer, I am working to isolate primary myoblasts from wild-type and LAMA2-mutant mice to study the molecular mechanisms of this disease in vitro and in vivo.
Peer-Reviewed Publications
Peer-Reviewed Publications
Pinheiro, A., & Naya, F. J. (2021). The Key Lnc (RNA) s in Cardiac and Skeletal Muscle Development, Regeneration, and Disease. Journal of Cardiovascular Development and Disease, 8(8), 84. [MDPI]
Dill, T. L., Carroll, A., Pinheiro, A., Gao, J., & Naya, F. J. (2021). The long noncoding RNA Meg3 regulates myoblast plasticity and muscle regeneration through epithelial-mesenchymal transition. Development, 148(2), dev194027. [PubMed]
Elder, S., Pinheiro, A., Young, C., Smith, P., & Wright, E. (2017). Evaluation of genipin for stabilization of decellularized porcine cartilage. Journal of Orthopaedic Research, 35(9), 1949-1957. [PubMed]
Pinheiro, A., Cooley, A., Liao, J., Prabhu, R., & Elder, S. (2016). Comparison of natural crosslinking agents for the stabilization of xenogenic articular cartilage. Journal of Orthopaedic Research, 34(6), 1037-1046. [PubMed]
Previous Research Projects
Previous Research Projects
Non-coding RNA and Epigenetic Modifications in Cardiac and Skeletal Muscle Development, Regeneration, and Disease
Non-coding RNA and Epigenetic Modifications in Cardiac and Skeletal Muscle Development, Regeneration, and Disease
This in depth literature study was investigated the key long non-coding RNAs which positively and negatively regulate skeletal muscle development and disease. A comprehensive version of this review, including cardiac muscle has been published the in Journal of Cardiovascular Development and Disease.
The Relationship of Bone Density and Body Composition Between Athletes and a General Population of College Age
The Relationship of Bone Density and Body Composition Between Athletes and a General Population of College Age
Though my masters thesis project, I investigated the relationship between bone density and body composition based on previously collected data. The results indicated clear sex-specific differences between the populations studied.
Polylimonene thioethere for Tissue Engineering Applications
Polylimonene thioethere for Tissue Engineering Applications
In the Langer Lab at MIT, I collaborated with Dr. Keith Hearon to optimize the rheology for a novel biomaterial and characterized the polymer used for cardiac tissue engineering applications.
Comparison of Natural Crosslinking Agents for the Stabilization of Xenogenic Cartilage
Comparison of Natural Crosslinking Agents for the Stabilization of Xenogenic Cartilage
Through an NSF funded project, I worked with Dr. Steve Elder to investigate the use of plant based crosslinking agents with low cytotoxicity. Genipin was determined to be best suited for crosslinking decellularized porcine cartilage for tissue engineering constructs.
Research Presentations
Research Presentations
Coordinating metabolism and differentiation through the Dlk1-Dio3 ncRNA locus
Coordinating metabolism and differentiation through the Dlk1-Dio3 ncRNA locus
Invited oral presentation at the 2023 Boston College Science on Tap Series (Chestnut Hill, MA)
Coordinating metabolism and differentiation through the Dlk1-Dio3 ncRNA locus
Coordinating metabolism and differentiation through the Dlk1-Dio3 ncRNA locus
Oral presentation at the 2023 Cold Spring Harbor Regulatory and Non-coding RNA Meeting (Cold Spring Harbor, NY)
Relationship of Bone Mineral Density and Body Composition in Student Athletes and College Aged Students
Relationship of Bone Mineral Density and Body Composition in Student Athletes and College Aged Students
Poster presentation at the American College of Sports Medicine 2019 Annual Meeting (Orlando, FL)
STEM Education through Sports
STEM Education through Sports
Oral presentation at the NEXT Conference 2018 (Akron, OH)
Polylimonene thioethere for Tissue Engineering Applications
Polylimonene thioethere for Tissue Engineering Applications
Poster presentation at the 2015 MIT Summer Research Program Symposium (Cambridge, MA)
Use of Natural Crosslinkers to Stabilize Decellularized Cartilage
Use of Natural Crosslinkers to Stabilize Decellularized Cartilage
Poster presentation at 2015 Biomedical Engineering Society (BMES) Meeting (Austin, TX)
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